
He is the younger brother of actors BB Gandanghari, Rommel Padilla and Royette Padilla.
In 2009, Padilla announced that he has been divorced from his wife Liezl Sicangco for two years and that Sicango has a new husband in Australia.
Padilla is currently dating Mariel Rodriguez who he met during his stint as a host of Wowowee. On August 7, 2010, he professed his love for Mariel Rodriguez and put a 1.2 million pesos worth (around 26,708.40 USD) diamond ring on her finger, live on national TV.